Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition

被引：39

作者：

Kinsman, OS ^{[1
]}

Chalk, PA ^{[1
]}

Jackson, HC ^{[1
]}

Middleton, RF ^{[1
]}

Shuttleworth, A ^{[1
]}

Rudd, BAM ^{[1
]}

Jones, CA ^{[1
]}

Noble, HM ^{[1
]}

Wildman, HG ^{[1
]}

Dawson, MJ ^{[1
]}

Stylli, C ^{[1
]}

Sidebottom, PJ ^{[1
]}

Lamont, B ^{[1
]}

Lynn, S ^{[1
]}

Hayes, MV ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 01期

关键词：

D O I：

10.7164/antibiotics.51.41

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel antifungal antibiotic GR135402 has been isolated from a fermentation broth of Graphium putredinis which inhibited protein synthesis in Candida albicans but not rabbit reticulocytes. The spectrum of activity included C. albicans and Cryptococcus neoformans but not some other Candida species or Aspergillus species. Therapeutic efficacy in a mouse model of systemic candidosis was attained following parenteral dosing.

引用

页码：41 / 49

页数：9

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