A practical gram-scale and high-yielding synthesis of the antimicrobial peptide gramicidin S is presented. An Fmoc-based solid-phase peptide synthesis protocol is employed for the generation of the linear decapeptide precursor, which is cyclized in solution to afford the target compound. The versatility of our method is demonstrated by the construction of eight gramicidin S analogues (15ah) having nonproteinogenic sugar amino acid residues (4-7) incorporated in the turn regions.
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Bu, XZ
Wu, XM
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机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Wu, XM
Ng, NLJ
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机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Ng, NLJ
Mak, CK
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机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Mak, CK
Qin, CG
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机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Qin, CG
Guo, ZH
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Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R ChinaHong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Bu, XZ
Wu, XM
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h-index: 0
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Wu, XM
Ng, NLJ
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h-index: 0
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Ng, NLJ
Mak, CK
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h-index: 0
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Mak, CK
Qin, CG
论文数: 0引用数: 0
h-index: 0
机构:Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China
Qin, CG
Guo, ZH
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h-index: 0
机构:
Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R ChinaHong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China