The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells

被引：16

作者：

Li, X ^{[1
]}

Wang, Y ^{[1
]}

Debatin, KM ^{[1
]}

Hug, H ^{[1
]}

机构：

[1] Univ Ulm, Kinderklin, D-89075 Ulm, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 277卷 / 02期

关键词：

HIPK2; CD95; TRADD; TNF-R1; FADD;

D O I：

10.1006/bbrc.2000.3700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIPK2 has been described as a homoedomain-interacting protein kinase with a nuclear localization. Here we describe that HIPK2 can also associate with TRADD, a protein that interacts with tumor necrosis factor receptor type 1 (TNF-R1). Under the conditions where HIPK2/TRADD association was found, no direct interaction of HIPK2 with CD95, TNF-R1, FADD or caspase-8 could be detected. Therefore, HIPK2 may play a role in TNF-R1 mediated signaling. (C) 2000 Academic Press.

引用

收藏

页码：513 / 517

页数：5

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