Negative regulation of TGF-β signaling in development

被引：25

作者：

Chen, YG ^{[1
]}

Meng, AM ^{[1
]}

机构：

[1] Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China

来源：

CELL RESEARCH | 2004年 / 14卷 / 06期

关键词：

TGF-beta; BMP; nodal; activin; antagonist; development; negative regulation;

D O I：

10.1038/sj.cr.7290246

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The TGF-beta superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signaling to regulate expression of their target genes. Despite of the relatively simple signal transduction pathway, many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms. This article reviews the negative regulation of TGF-beta signaling with focus on its roles in vertebrate development.

引用

收藏

页码：441 / 449

页数：9

相关论文

共 105 条

[1] FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].

Accili, D ;

Arden, KC .

CELL, 2004, 117 (04) :421-426

[2] Autonomous neural axis formation by ectopic expression of the protooncogene c-ski [J].

Amaravadi, LS ;

Neff, AW ;

Sleeman, JP ;

Smith, RC .

DEVELOPMENTAL BIOLOGY, 1997, 192 (02) :392-404

[3]

Anderson RM, 2002, DEVELOPMENT, V129, P4975

[4] Local inhibition and long-range enhancement of Dpp signal transduction by Sog [J].

Ashe, HL ;

Levine, M .

NATURE, 1999, 398 (6726) :427-431

[5] Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans [J].

Belenkaya, TY ;

Han, C ;

Yan, D ;

Opoka, RJ ;

Khodoun, M ;

Liu, HZ ;

Lin, XH .

CELL, 2004, 119 (02) :231-244

[6] PP1 binds Sara and negatively regulates Dpp signaling in Drosophila melanogaster [J].

Bennett, D ;

Alphey, L .

NATURE GENETICS, 2002, 31 (04) :419-423

[7] Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development [J].

Berk, M ;

Desai, SY ;

Heyman, HC ;

Colmenares, C .

GENES & DEVELOPMENT, 1997, 11 (16) :2029-2039

[8] Autocrine/paracrine regulation of pituitary function by activin, inhibin and follistatin [J].

Bilezikjian, LM ;

Blount, AL ;

Leal, AMO ;

Donaldson, CJ ;

Fischer, WH ;

Vale, WW .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2004, 225 (1-2) :29-36

[9] Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton [J].

Brunet, LJ ;

McMahon, JA ;

McMahon, AP ;

Harland, RM .

SCIENCE, 1998, 280 (5368) :1455-1457

[10] Bone morphogenetic proteins, their antagonists, and the skeleton [J].

Canalis, E ;

Economides, AN ;

Gazzerro, E .

ENDOCRINE REVIEWS, 2003, 24 (02) :218-235

← 1 2 3 4 5 6 7 8 9 10 →