Chemotherapy-induced noncardiogenic pulmonary edema related to gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor support

被引:20
作者
Briasoulis, E
Froudarakis, M
Milionis, H
Peponis, I
Constantopoulos, S
Pavlidis, N
机构
[1] Ioannina Univ Hosp, Dept Med Oncol, Ioannina, Greece
[2] Ioannina Univ Hosp, Dept Pneumol, Ioannina, Greece
[3] Ioannina Univ Hosp, Dept Internal Med, Ioannina, Greece
关键词
chemotherapy; gemcitabine; docetaxel; granulocyte colony-stimulating factor; pulmonary toxicity; noncardiogenic pulmonary edema;
D O I
10.1159/000056300
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Several cancer therapeutic agents have been associated with pulmonary toxicity. Herein, we describe the case of a 73-year-old woman with breast cancer metastatic to the liver, who developed noncardiogenic pulmonary edema (NPE) while on treatment with gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor (G-CSF) support. Gemcitabine, a deoxycytidine analogue, is reported to produce mild self-limiting and only occasionally severe pulmonary toxicity. The microtubule stabilizer docetaxel has been associated with water retention complications. The combination of these two agents has shown promising activity in several solid tumors and is in a phase of clinical development with prophylactic G-CSF in most of the trials due to the high rate of dose-limiting neutropenia observed with this combination. In our case pulmonary toxicity resolved rapidly following the administration of corticosteroids. A possible deleterious synergy of the compounds involved in this case is discussed and the medical literature on NPE related to cancer therapy is shortly reviewed. We conclude that NPE should always be considered in patients with respiratory function deterioration while on therapy with the gemcitabine-docetaxel combination and G-CSF. Corticosteroids can provide maximum benefit if started early upon diagnosis coupled with withdrawal of the causative drugs. Copyright (C) 2000 S. Karger AG, Basel.
引用
收藏
页码:680 / 683
页数:4
相关论文
共 31 条
[1]   Gemcitabine - a safety review [J].
Aapro, MS ;
Martin, C ;
Hatty, S .
ANTI-CANCER DRUGS, 1998, 9 (03) :191-201
[2]   REPORT OF THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ACUTE RESPIRATORY-DISTRESS SYNDROME - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].
BERNARD, GR ;
ARTIGAS, A ;
BRIGHAM, KL ;
CARLET, J ;
FALKE, K ;
HUDSON, L ;
LAMY, M ;
LEGALL, JR ;
MORRIS, A ;
SPRAGG, R ;
Cochin, B ;
Lanken, PN ;
Leeper, KV ;
Marini, J ;
Murray, JF ;
Oppenheimer, L ;
Pesenti, A ;
Reid, L ;
Rinaldo, J ;
Villar, J ;
van Asbeck, BS ;
Dhainaut, JF ;
Mancebo, J ;
Matthay, M ;
Meyrick, B ;
Payen, D ;
Perret, C ;
Fowler, AA ;
Schaller, MD ;
Hudson, LD ;
Hyers, T ;
Knaus, W ;
Matthay, R ;
Pinsky, M ;
Bone, RC ;
Bosken, C ;
Johanson, WG ;
Lewandowski, K ;
Repine, J ;
Rodriguez-Roisin, R ;
Roussos, C ;
Antonelli, MA ;
Beloucif, S ;
Bihari, D ;
Burchardi, H ;
LeMaire, F ;
Montravers, P ;
Petty, TL ;
Robotham, J ;
Zapol, W .
JOURNAL OF CRITICAL CARE, 1994, 9 (01) :72-81
[3]   Severe pulmonary toxicity in patients treated with a combination of docetaxel and gemcitabine for metastatic transitional cell carcinoma [J].
Dunsford, ML ;
Mead, GM ;
Bateman, AC ;
Cook, T ;
Tung, K .
ANNALS OF ONCOLOGY, 1999, 10 (08) :943-947
[4]  
Etienne B, 1998, REV MAL RESPIR, V15, P199
[5]   Front-line treatment of advanced non-small-cell lung cancer with docetaxel and gemcitabine: A multicenter phase II trial [J].
Georgoulias, V ;
Kouroussis, C ;
Androulakis, N ;
Kakolyris, S ;
Dimopoulos, MA ;
Papadakis, E ;
Bouros, D ;
Apostolopoulou, F ;
Papadimitriou, C ;
Agelidou, A ;
Hatzakis, K ;
Kalbakis, K ;
Kotsakis, A ;
Vardakis, N ;
Vlachonicolis, J .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (03) :914-920
[6]   ACTIVITY AND UNEXPECTED LUNG TOXICITY OF THE SEQUENTIAL ADMINISTRATION OF 2 ALKYLATING-AGENTS - DACARBAZINE AND FOTEMUSTINE IN PATIENTS WITH MELANOMA [J].
GERARD, B ;
AAMDAL, S ;
LEE, SM ;
LEYVRAZ, S ;
LUCAS, C ;
DINCALCI, M ;
BIZZARI, JP .
EUROPEAN JOURNAL OF CANCER, 1993, 29A (05) :711-719
[7]   ARA-C LUNG - NONCARDIOGENIC PULMONARY-EDEMA COMPLICATING CYTOSINE-ARABINOSIDE THERAPY OF LEUKEMIA [J].
HAUPT, HM ;
HUTCHINS, GM ;
MOORE, GW .
AMERICAN JOURNAL OF MEDICINE, 1981, 70 (02) :256-261
[8]   G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia [J].
Hierholzer, C ;
Kelly, E ;
Lyons, V ;
Roedling, E ;
Davies, P ;
Billiar, TR ;
Tweardy, DJ .
JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (02) :169-174
[9]  
Kitamura S, 1997, Masui, V46, P946
[10]  
KREISMAN H, 1992, SEMIN ONCOL, V19, P508