Prognostic Classification and Risk Assessment in Myelodysplastic Syndromes

被引：36

作者：

Cazzola, Mario ^{[1
]}

Malcovati, Luca ^{[1
]}

机构：

[1] Univ Pavia, Policlin San Matteo, Fdn IRCCS, Dept Hematol Oncol,Med Sch, I-27100 Pavia, Italy

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2010年 / 24卷 / 02期

关键词：

Myelodysplastic syndrome; Acute myeloid leukemia; Anemia; Transfusion; Prognosis; WORLD-HEALTH-ORGANIZATION; ACUTE MYELOID-LEUKEMIA; COMORBIDITY INDEX; SCORING SYSTEM; IRON OVERLOAD; TRANSPLANTATION; TET2; GUIDELINES; RELEVANCE; SURVIVAL;

D O I：

10.1016/j.hoc.2010.02.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical heterogeneity of myelodysplastic syndromes (MDS) is best illustrated by the observation that these disorders range from indolent conditions with a near-normal life expectancy to forms approaching acute myeloid leukemia (AML). A risk-adapted treatment strategy is mandatory for conditions showing a highly variable clinical course, and definition of the individual risk has been based so far on the use of prognostic scoring systems. The authors have developed a prognostic model that accounts for the World Health Organization (WHO) categories, cytogenetics, transfusion dependency, and bone marrow fibrosis. This WHO classification-based Prognostic Scoring System (W PSS) is able to classify patients into five risk groups showing different survivals and probabilities of leukemic evolution. WPSS predicts survival and leukemia progression at any time during follow-up, and may therefore be used for implementing risk-adapted treatment strategies.

引用

页码：459 / +

页数：11

共 34 条

[1] WHO classification and WPSS predict posttransplantation outcome in patients with myelodysplastic syndrome:: a study from the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) [J].

Alessandrino, Emilio Paolo ;

Della Porta, Matteo Giovanni ;

Bacigalupo, Andrea ;

Van Lint, Maria Teresa ;

Falda, Michele ;

Onida, Francesco ;

Bernardi, Massimo ;

Iori, Anna Paola ;

Rambaldi, Alessandro ;

Cerretti, Raffaella ;

Marenco, Paola ;

Pioltelli, Pietro ;

Malcovati, Luca ;

Pascutto, Cristiana ;

Oneto, Rosi ;

Fanin, Renato ;

Bosi, Alberto ;

Levis, A. ;

Rambaldi, A. ;

Bandini, G. ;

Casini, M. ;

Rossi, G. ;

Angelucci, E. ;

Baronciani, D. ;

La Nasa, G. ;

Milone, G. ;

Mordini, N. ;

Guidi, S. ;

Bosi, A. ;

Bacigalupo, A. ;

Van Lint, M. T. ;

Corradini, P. ;

Milani, R. ;

Morra, E. ;

Marenco, P. ;

Deliliers, G. Lambretenghi ;

Onida, F. ;

Ciceri, F. ;

Bernardi, M. ;

Castagna, L. ;

Narni, F. ;

Pioltelli, P. ;

Selleri, Carmine ;

Scime, R. ;

Iannitto, E. ;

Musso, M. ;

Alessandrino, E. P. ;

Locatelli, F. ;

Martelli, F. ;

Visani, G. .

BLOOD, 2008, 112 (03) :895-902

[2]

Alessandrino EP, 2002, HAEMATOLOGICA, V87, P1286

[3]

[Anonymous], 2008, WHO CLASSIFICATION T

[4]

BENNETT JM, 1982, BRIT J HAEMATOL, V51, P189, DOI 10.1111/j.1365-2141.1982.tb08475.x

[5] Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellular myelodysplastic syndromes and aplastic anemia: recommendations for a standardized approach [J].

Bennett, John M. ;

Orazi, Attilio .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (02) :264-269

[6] Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes [J].

Bowen, D ;

Culligan, D ;

Jowitt, S ;

Kelsey, S ;

Mufti, G ;

Oscier, D ;

Parker, J .

BRITISH JOURNAL OF HAEMATOLOGY, 2003, 120 (02) :187-200

[7]

Brunning RD., 2008, WHO CLASSIFICATION T, P88

[8]

CAZZOLA, 2009, HEMATOLOGY ED, V3, P181

[9]

CAZZOLA M, 1988, BLOOD, V71, P305

[10] Myelodysplastic syndromes - Coping with ineffective hematopoiesis [J].

Cazzola, M ;

Malcovati, L .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (06) :536-538

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