Jimenezin, a novel annonaceous acetogenin from the seeds of Rollinia mucosa containing adjacent tetrahydrofuran-tetrahydropyran ring systems

被引：45

作者：

Chávez, D

Acevedo, LA

Mata, R ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Quim, Unidad Invest Plantas Med, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 04期

关键词：

D O I：

10.1021/np970510f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cytotoxic acetogenin, jimenezin (1), containing a hydroxylated tetrahydropyran ring along with an adjacent tetrahydrofuran ring and representing a novel carbon skeleton, was isolated from the seeds of Rollinia mucosa. The structure was elucidated by means of chemical and spectral methods including MS and NMR measurements. Compound 1 exhibited potent cytotoxic activity against six human solid tumor cell lines.

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页码：419 / 421

页数：3

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