Obesity and Cancer: The Oil that Feeds the Flame

被引：321

作者：

Font-Burgada, Joan ^{[1
,2
]}

Sun, Beicheng ^{[3
,4
]}

Karin, Michael ^{[1
,2
]}

机构：

[1] UCSD, Sch Med, Moores Canc Ctr, Dept Pharmacol,Lab Gene Regulat & Signal Transduc, La Jolla, CA 92093 USA

[2] UCSD, Sch Med, Moores Canc Ctr, Dept Pathol,Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[3] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Ctr Canc, Nanjing, Jiangsu, Peoples R China

来源：

CELL METABOLISM | 2016年 / 23卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; NECROSIS-FACTOR-ALPHA; ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; BODY-MASS INDEX; NF-KAPPA-B; PROMOTES INTESTINAL CARCINOGENESIS; INDUCED INSULIN-RESISTANCE; HUMAN GUT MICROBIOME; HEPATOCELLULAR-CARCINOMA;

D O I：

10.1016/j.cmet.2015.12.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Although discussion of the obesity epidemic had become a cocktail party cliche, its impact on public health cannot be dismissed. In the past decade, cancer had joined the list of chronic debilitating diseases whose risk is substantially increased by hypernutrition. Here we discuss recent advances in understanding how obesity increases cancer risk and propose a unifying hypothesis according to which the major tumor-promoting mechanism triggered by hypernutrition is the indolent inflammation that takes place at particular organ sites, including liver, pancreas, and gastrointestinal tract. The mechanisms by which excessive fat deposition feeds this tumor-promoting inflammatory flame are diverse and tissue specific.

引用

页码：48 / 62

页数：15

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