Cucurbitane glycosides from unripe fruits of Siraitia grosvenori

被引：32

作者：

Li, Dianpeng

Ideda, Tsuyoshi

Nohara, Toshihiro

Liu, Jinlei

Wen, Yongxin

Sakamoto, Tatsunori

Nonaka, Gen-Ichiro

机构：

[1] Kumamoto Univ, Fac Med & Pharmaceut Sci, Kumamoto 8620973, Japan

[2] Chinese Acad Sci, Guanxi Inst Bot, Guilin 541006, Peoples R China

[3] Sakamoto Limestone Ind Co Ltd, Kumamoto 8650013, Japan

[4] Nonaka Usaien Pharmaceut Co Let, Saga 8400055, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 07期

关键词：

Siraitia grosvenori; Lo Han Kuo; cucurbitane-glycoside; unripe fruit; cytotoxic activity; FRUCTUS MOMORDICAE;

D O I：

10.1248/cpb.55.1082

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Studies on the constituents of the unripe fruits of Siraitia grosvenori led to the isolation of three new cucurbitane triterpene glycosides, 11-oxomogroside III (10), 11-dehydroxymogroside III (11), and 11-oxomogroside IV A (12). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods. All of the compounds isolated from the unripe fruits of S. grosvenori were tested for cytotoxic activities against tumor cells, HCT-116 and SMMC-7721.

引用

页码：1082 / 1086

页数：5

共 17 条

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[Anonymous], 1996, ACTA BOT SIN

[2]

CHANG Q, 1994, CHIN J MAG RES, V11, P43

[3]

Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on nasal rubbing and scratching behavior in ICR mice [J].