Decline of measles-specific immunoglobulin M antibodies after primary measles, mumps, and rubella vaccination

被引:14
作者
Helfand, RF
Gary, HE
Atkinson, WL
Nordin, JD
Keyserling, HL
Bellini, WJ
机构
[1] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA
[2] Ctr Dis Control & Prevent, Natl Immunizat Program, Atlanta, GA 30333 USA
[3] Emory Univ, Atlanta, GA 30322 USA
[4] Grp Hlth Fdn, Minneapolis, MN 55440 USA
关键词
D O I
10.1128/CDLI.5.2.135-138.1998
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Detection of measles-specific immunoglobulin M (IgM) has become the standard diagnostic method for laboratory confirmation of measles, In outbreaks, the interpretation of an IgM-positive result can be complicated when persons with suspected measles receive a dose of measles vaccine as part of outbreak control measures. This investigation evaluated the decay of measles-specific IgM antibodies 1 to 4 months after primary vaccination with measles, mumps, and rubella vaccine (MMRII). Serum samples were obtained from 536 infants vaccinated when they were 15 months old as part of a study to assess primary and secondary measles vaccine failure, Sixty serum specimens per week were selected from specimens collected between 4 and 9 weeks after MMRII vaccination; all 176 available serum specimens collected between 10 and greater than or equal to 16 weeks were included, Specimens were tested for the presence of measles-specific IgM by an antibody-capture enzyme immunoassay. The proportion of IgM-positive specimens dropped from 73% at 4 weeks after vaccination to 52% at 5 weeks after vaccination and then declined to 7% by 8 weeks after vaccination. Less than 10% of children remained IgM positive between 9 and 11 weeks, An IgM-negative result helps rule out the diagnosis of measles in a person with suspected infection and a history of recent vaccination, The interpretation of a positive IgM result from a person with a clinically suspected case of measles and a recent history of measles vaccination (especially within 8 weeks) is problematic, and the diagnosis of measles should be based on epidemiologic linkage to a confirmed case or on detection of wild-type measles virus.
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页码:135 / 138
页数:4
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