Arnoamines A and B, new cytotoxic pentacyclic pyridoacridine alkaloids from the ascidian Cystodytes sp.

被引：40

作者：

Plubrukarn, A

Davidson, BS ^{[1
]}

机构：

[1] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA

[2] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 05期

关键词：

D O I：

10.1021/jo9719721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new cytotoxic pyridoacridine alkaloids, arnoamines A (1) and B (2), have been isolated from the ascidian Cystodytes sp. collected in the vicinity of Arno Atoll, Republic of Marshall Islands. Compounds 1 and 2 are proposed to be the first members of a new class of pentacyclic pyridoacridine alkaloids possessing a pyrrole ring fused to the pyridoacridine ring system. The structures of 1 and 2 were proposed on the basis of the interpretation of spectroscopic data, particularly those obtained from HMBC and NOE NMR experiments. The arnoamines were unexpectedly found to incorporate deuterium at C-10 and C-11 of the pyrrole ring when dissolved in CDCl3/TFA-d.

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页码：1657 / 1659

页数：3

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