Chronic caffeine treatment attenuates experimental autoimmune encephalomyelitis induced by guinea pig spinal cord homogenates in Wistar rats

被引：75

作者：

Chen, Guo Qian ^{[1
,2
]}

Chen, Yan Yan ^{[1
,2
]}

Wang, Xin Shi ^{[1
,2
]}

Wu, Sai Zhen ^{[1
,2
]}

Yang, Hui Min ^{[1
,2
]}

Xu, Hui Qin ^{[1
,2
]}

He, Jin Cai ^{[1
,2
]}

Wang, Xiao Tong ^{[1
,2
]}

Chen, Jiang Fan ^{[1
,2
,3
]}

Zheng, Rong Yuan ^{[1
,2
]}

机构：

[1] Wenzhou Med Coll, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China

[2] Wenzhou Med Coll, Res Inst Expt Neurobiol, Wenzhou 325000, Zhejiang, Peoples R China

[3] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

来源：

BRAIN RESEARCH | 2010年 / 1309卷

关键词：

Caffeine; Experimental autoimmune encephalomyelitis (EAE); Adenosine receptor; A1; receptor; A2A receptor; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; ADENOSINE; MICE; NEUROPROTECTION; BRAIN; DEMYELINATION; EXPRESSION; DISEASE;

D O I：

10.1016/j.brainres.2009.10.054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Dysfunction of adenosinergic systems has been implicated in the development of multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in animals. Caffeine, a non-selective antagonist of adenosine receptors, has been shown to provide protection against myelin oligodendroglia. glycoprotein (MOG)-induced EAE in mice. In this study, we showed that chronic caffeine similarly imparts neuroprotection against EAE induced in rats by guinea pig spinal cord homogenates (GPSCH). GPSCH-induced EAE is characterized by extensive tissue inflammation with a typical chronic disease course. We showed that caffeine decreases the incidence of EAE and attenuates EAE pathology at behavioral, histological (inflammatory cell infiltration and demyelination) and neurochemical (expression of inflammatory cytokines) levels. The attenuation of GPSCH-induced pathology by chronic caffeine treatment was observed at doses of 10 and 30 mg/kg and during both peak and recovery phases of EAE. Furthermore, it was showed that chronic treatment with caffeine up-regulated A1 receptor and TGF-beta mRNAs and suppressed interferon-gamma mRNA in EAE rats. Together with previous reports, our data demonstrates that chronic treatment with caffeine exerts a neuroprotective effect against EAE, possibly through an A(1) receptor-mediated shift from Th1 to Th2 cell function, and provides a neurobiological basis for epidemiological investigation into the possible relationship between caffeine consumption and development of multiple sclerosis in humans. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：116 / 125

页数：10

共 32 条

[1]

ANNA T, 2004, J IMMUNOL, V172, P186

[2]

Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain β-amyloid production [J].