Dipole source localization and fMRI of simultaneously recorded data applied to somatosensory categorization

被引:48
作者
Thees, S
Blankenburg, F
Taskin, B
Curio, G
Villringer, A
机构
[1] Humboldt Univ, Univ Hosp, Charite, Dept Neurol, Berlin, Germany
[2] Free Univ Berlin, Benjamin Franklin Univ Hosp, D-1000 Berlin, Germany
关键词
EEG; event-related potentials; ERP; dipole source localization; fMRI; somatosensory system; secondary somatosensory cortex; parietal operculum; SMA; choice reaction task; somatosensory categorization;
D O I
10.1016/S1053-8119(02)00054-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this study, the feasibility of dipole source localization (DSL) and coregistration with functional magnetic resonance imaging (fMRI) activation patterns on the basis of. simultaneously acquired data is demonstrated. Brain activity was mapped during the performance of a somatosensory single reaction and a choice reaction task at high spatiotemporal resolution in six healthy subjects. The choice reaction task required a categorization of two different stimulus intensities, whereas for the single reaction task merely the perception of a tactile stimulus had to be confirmed by the subjects. An offline artifact correction algorithm was applied to 32-channel EEG data that were acquired between subsequent MRI scans. Using a multiple dipole approach, five distinct dipole sources were identified within areas of the somatosensory system. Coregistration of fMRI and DSL showed consistent spatial activation patterns with a mean distance of 9.2 +/- 6.8 mm between dipole sources and fMRI activation maxima. However, since the number of fMRI activation sites exceeded the number of cerebral dipole sources, it was not possible to assign a dipole source to each fMRI activation site. Dipole moment time courses were consistent with previously reported results of similar experiments. A comparison of brain activation patterns during the two tasks with both fMRI and DSL indicated an involvement of the contralateral secondary somatosensory cortex in somatosensory categorization. (C) 2003 Elsevier Science (USA). All rights reserved.
引用
收藏
页码:707 / 719
页数:13
相关论文
共 75 条
[1]   Identification of EEG events in the MR scanner: The problem of pulse artifact and a method for its subtraction [J].
Allen, PJ ;
Polizzi, G ;
Krakow, K ;
Fish, DR ;
Lemieux, L .
NEUROIMAGE, 1998, 8 (03) :229-239
[2]   A method for removing imaging artifact from continuous EEG recorded during functional MRI [J].
Allen, PJ ;
Josephs, O ;
Turner, R .
NEUROIMAGE, 2000, 12 (02) :230-239
[3]   HUMAN CORTICAL POTENTIALS-EVOKED BY STIMULATION OF THE MEDIAN NERVE .2. CYTOARCHITECTONIC AREAS GENERATING LONG-LATENCY ACTIVITY [J].
ALLISON, T ;
MCCARTHY, G ;
WOOD, CC ;
WILLIAMSON, PD ;
SPENCER, DD .
JOURNAL OF NEUROPHYSIOLOGY, 1989, 62 (03) :711-722
[4]   HUMAN CORTICAL POTENTIALS-EVOKED BY STIMULATION OF THE MEDIAN NERVE .1. CYTOARCHITECTONIC AREAS GENERATING SHORT-LATENCY ACTIVITY [J].
ALLISON, T ;
MCCARTHY, G ;
WOOD, CC ;
DARCEY, TM ;
SPENCER, DD ;
WILLIAMSON, PD .
JOURNAL OF NEUROPHYSIOLOGY, 1989, 62 (03) :694-710
[5]   TOPOGRAPHY AND INTRA-CRANICAL SOURCES OF SOMATOSENSORY EVOKED-POTENTIALS IN THE MONKEY .2. CORTICAL COMPONENTS [J].
AREZZO, JC ;
VAUGHAN, HG ;
LEGATT, AD .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1981, 51 (01) :1-18
[6]   Somatosensory cortex responses to median nerve stimulation: fMRI effects of current amplitude and selective attention [J].
Backes, WH ;
Mess, WH ;
van Kranen-Mastenbroek, V ;
Reulen, JPH .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (10) :1738-1744
[7]   The role of higher-order motor areas in voluntary movement as revealed by high-resolution EEG and fMRI [J].
Ball, T ;
Schreiber, A ;
Feige, B ;
Wagner, M ;
Lücking, CH ;
Kristeva-Feige, R .
NEUROIMAGE, 1999, 10 (06) :682-694
[8]   TIME COURSE EPI OF HUMAN BRAIN-FUNCTION DURING TASK ACTIVATION [J].
BANDETTINI, PA ;
WONG, EC ;
HINKS, RS ;
TIKOFSKY, RS ;
HYDE, JS .
MAGNETIC RESONANCE IN MEDICINE, 1992, 25 (02) :390-397
[9]   Stereotactic recordings of median nerve somatosensory-evoked potentials in the human pre-supplementary motor area [J].
Barba, C ;
Frot, M ;
Guénot, M ;
Mauguière, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (02) :347-356
[10]   Spatiotemporal brain imaging of visual-evoked activity using interleaved EEG and fMRI recordings [J].
Bonmassar, G ;
Schwartz, DP ;
Liu, AK ;
Kwong, KK ;
Dale, AM ;
Belliveau, JW .
NEUROIMAGE, 2001, 13 (06) :1035-1043