Reduced threshold for cortical spreading depression in female mice

被引：93

作者：

Brennan, Kevin C.

Romero Reyes, Marcela

Lopez Valdes, Hector E.

Arnold, Arthur P.

Charles, Andrew C.

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Geffen Sch Med, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Dept Physiol, Los Angeles, CA 90024 USA

来源：

ANNALS OF NEUROLOGY | 2007年 / 61卷 / 06期

关键词：

D O I：

10.1002/ana.21138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57B1/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.

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页码：603 / 606

页数：4

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