Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells

被引：21

作者：

Aoukaty, A

Lee, IF

Wu, J

Tan, RS

机构：

[1] British Columbia Childrens Hosp, Dept Pathol & Lab Med, Vancouver, BC V6H 2V4, Canada

[2] Univ British Columbia, Vancouver, BC V6H 2V4, Canada

[3] British Columbia Childrens Hosp, Dept Pediat, Vancouver, BC V6H 2V4, Canada

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2003年 / 23卷 / 02期

基金：

加拿大健康研究院;

关键词：

chronic active Epstein-Barr virus infection; natural killer cells;

D O I：

10.1023/A:1022580929226

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic active Epstein-Barr virus (CAEBV) infection is an uncommon and severe manifestation of EBV infection that frequently leads to the development of natural killer (NK) or T cell lymphomas. We report here that NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired interferon-gamma secretion against a variety of transformed target cell lines. In addition, NK cells from the patient lacked expression of the broadly expressed NK receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). These data suggest that CAEBV is associated with low expression of LAIR-1 on NK cells.

引用

页码：141 / 145

页数：5

共 11 条

[1] Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase [J].