Hematopoetic Stem Cell Transplantation in Neutrophil Disorders: Severe Congenital Neutropenia, Leukocyte Adhesion Deficiency and Chronic Granulomatous Disease

被引：14

作者：

Elhasid, Ronit ^{[1
]}

Rowe, Jacob M. ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Rappaport Sch Med, Div Hematol, IL-31096 Haifa, Israel

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2010年 / 38卷 / 01期

关键词：

Severe congenital neutropenia; Leukocyte adhesion deficiency; Chronic granulomatous disease; Hematopoietic stem cell transplantation (HSCT); BONE-MARROW-TRANSPLANTATION; COLONY-STIMULATING FACTOR; GENE-THERAPY; LEUKEMIC TRANSFORMATION; HEMATOPOIETIC ALLOGRAFT; KOSTMANN-SYNDROME; CSF3R MUTATIONS; UNRELATED DONOR; LAD-III; RECEPTOR;

D O I：

10.1007/s12016-009-8129-y

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Until further progress will occur in the field of gene therapy, the only curative treatment available in severe congenital neutropenia, leukocyte adhesion deficiency, and chronic granulomatous disease is allogeneic hematopoietic stem cell transplantation (HSCT). This review summarizes the current data regarding indications for transplantation in each disease, treatment results using related and unrelated donors, as well as toxicity of HSCT in the above diseases.

引用

页码：61 / 67

页数：7

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