Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein

被引：122

作者：

Krall, R

Schmidt, G

Aktories, K

Barbieri, JT

机构：

[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[2] Univ Freiburg, Inst Pharmakol & Toxikol, D-79104 Freiburg, Germany

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 10期

关键词：

D O I：

10.1128/IAI.68.10.6066-6068.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization, Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.

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页码：6066 / 6068

页数：3

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