Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain

被引:16
作者
Tohda, M [1 ]
Watanabe, H [1 ]
机构
[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DIV PHARMACOL,SUGITANI,TOYAMA 93001,JAPAN
关键词
5-HT2C receptor; antidepressant; digoxigenin; in situ hybridization; rat brain;
D O I
10.1016/0168-0102(95)00992-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Repeated oral administration of 20 mg/kg imipramine elevated the level of 5-HT2C mRNA in the rat brain. Hybridization signals in nearly all regions stained by digoxigenin-labeled antisense cRNA probe, such as the hippocampus, choroid plexus, habenular nucleus, and dorsomedial hypothalamic nucleus, were more intense following imipramine treatment. These results suggest that long-term treatment with imipramine stimulates 5-HT2C receptor gene expression.
引用
收藏
页码:189 / 193
页数:5
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