Targeting autophagy in cancer

被引：2672

作者：

Levy, Jean M. Mulcahy ^{[1
,2
,3
]}

Towers, Christina G. ^{[3
]}

Thorburn, Andrew ^{[3
]}

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA

[2] Childrens Hosp Colorado, Morgan Adams Fdn, Pediat Brain Tumor Res Program, Aurora, CO 80045 USA

[3] Univ Colorado, Sch Med, Dept Pharmacol, Aurora, CO 80045 USA

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 09期

关键词：

CHAPERONE-MEDIATED AUTOPHAGY; HYPOXIA-INDUCED AUTOPHAGY; ADVANCED SOLID TUMORS; PHASE-I TRIAL; BREAST-CANCER; ER STRESS; CISPLATIN RESISTANCE; SURVIVAL MECHANISM; INHIBITS AUTOPHAGY; HMGB1; EXPRESSION;

D O I：

10.1038/nrc.2017.53

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.

引用

页码：528 / 542

页数：15

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