Bcl-2 and Bax proteins in Lewy bodies from patients with Parkinson's disease and diffuse Lewy body disease

被引：35

作者：

Tortosa, A

López, E

Ferrer, I ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Llobregal, Hosp Princeps Espanya, Serv Anat Patol,Unitat Neuropatol, Barcelona 08907, Spain

[2] Univ Barcelona, Hosp Llobregat, Fonamental Med Quin, Dept Infermeria, Barcelona 08907, Spain

[3] Univ Barcelona, Hosp Llobregat, Dept Biol Cellular & Anat Patol, Barcelona 08907, Spain

来源：

NEUROSCIENCE LETTERS | 1997年 / 238卷 / 1-2期

关键词：

Bcl-2; Bax; Lewy bodies; Parkinson's disease; Diffuse Lewy body disease;

D O I：

10.1016/S0304-3940(97)00837-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Double-labelling immunohistochemistry of Bcl-2 and Bax, and ubiquitin (as a marker of Lewy bodies) was examined in the brains of patients with Parkinson's disease and Diffuse Lewy body disease to learn about possible modifications of protein expression and the presence of Lewy bodies, Bcl-2 and Bax immunoreactivities were observed in Lewy body-bearing and non-Lewy body-bearing neurons in patients with parkinsonism. These results show that Bcl-2 and Bax are probably not implicated in Lewy body formation and that the presence of Lewy bodies does not have a direct impact on the expression of Bcl-2 and Bax proteins in individual neurons. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：78 / 80

页数：3

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