The DNA revolution in population genetics

被引：123

作者：

Cavalli-Sforza, LL ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(97)01327-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Unprecedented clarity has come to our understanding of genetic variation by the analysis of DNA sequences. It is not surprising that the new DNA technologies are leading to a resurgence of interest in population genetics, In this review, I discuss recent progress and future directions towards reconstructing the history of human populations, There is increasing consensus on a recent 'Out of Africa' origin of modern humans, which explains why the greatest fraction of genetic diversity is found within populations, rather than between them. The comparison of Y chromosome and mitochondrial DNA data shows remarkable sex differences in geographic variation. The analysis of Neanderthal DNA has been a major breakthrough in the study of fossil DNA. Among major hopes for the future are applications to polygenic diseases.

引用

页码：60 / 65

页数：6

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