Anthrax capsule vaccine protects against experimental infection

被引：73

作者：

Chabot, DJ ^{[1
]}

Scorpio, A ^{[1
]}

Tobery, SA ^{[1
]}

Little, SF ^{[1
]}

Norris, SL ^{[1
]}

Friedlander, AM ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Frederick, MD 21701 USA

来源：

VACCINE | 2004年 / 23卷 / 01期

关键词：

anthrax; vaccine; capsule;

D O I：

10.1016/j.vaccine.2004.05.029

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Efficacy of a poly-gamma-D-glutamic acid anthrax capsule vaccine was assessed in a mouse model of infection. Capsule by itself was protective against lethal challenge with a toxin(-), capsule(+) Bacillus anthracis strain. Conjugation of capsule to bovine serum albumin resulted in enhanced IgG anti-capsule antibodies measured by ELISA, but completely abrogated the protection. The protective unconjugated capsule vaccine elicited significantly higher IgM titers and opsonic activity than did the non-protective capsule conjugate. When tested against a fully virulent toxin(+), capsule(+) B. anthracis strain, neither capsule nor protective antigen alone was protective. However, the combination of the two protected against a lethal challenge. These results suggest that capsule may enhance the protection afforded by protective antigen vaccines against anthrax if opsonizing antibodies are produced. Surprisingly, some protection was also observed when protective antigen was conjugated to itself. (C) 2004 Published by Elsevier Ltd.

引用

页码：43 / 47

页数：5

共 25 条

[1] Vaccination against anthrax with attenuated recombinant strains of Bacillus anthracis that produce protective antigen [J].