PASS: prediction of activity spectra for biologically active substances

被引：723

作者：

Lagunin, A ^{[1
]}

Stepanchikova, A ^{[1
]}

Filimonov, D ^{[1
]}

Poroikov, V ^{[1
]}

机构：

[1] Russian Acad Med Sci, Lab Struct Funct Based Drug Design, Inst Biomed Chem, Moscow 119832, Russia

来源：

BIOINFORMATICS | 2000年 / 16卷 / 08期

关键词：

D O I：

10.1093/bioinformatics/16.8.747

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of the biological activity spectrum was introduced to describe the properties of biologically active substances. The PASS (prediction of activity spectra for substances) software product, which predicts more than 300 pharmacological effects and biochemical mechanisms on the basis of the structural formula of a substance, may be efficiently used to find new targets (mechanisms) for some ligands and, conversely, to reveal new ligand's for some biological targets. We have developed a WWW interface for the PASS software. A WWW server for the on-line prediction of the biological activity spectra of substances has been constructed.

引用

页码：747 / 748

页数：2