CD40 and autoimmunity: The dark side of a great activator

被引：218

作者：

Peters, Anna L. ^{[2
,3
]}

Stunz, Laura L.

Bishop, Gail A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Iowa, Dept Microbiol, Med Educ & Res Facil 2193B, Iowa City, IA 52242 USA

[2] Univ Iowa, Grad Program Immunol, Iowa City, IA 52242 USA

[3] Univ Iowa, Med Sci Training Program, Iowa City, IA 52242 USA

[4] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

[5] VA Med Ctr, Iowa City, IA 52242 USA

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 05期

关键词：

CD40; CD154; Autoimmune disease; Polymorphism; T lymphocyte; B lymphocyte; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTI-CD40 LIGAND ANTIBODY; SINGLE-NUCLEOTIDE POLYMORPHISM; NONOBESE DIABETIC MICE; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; CD4(+) T-CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; RHEUMATOID SYNOVIAL FIBROBLASTS; INFLAMMATORY-BOWEL-DISEASE;

D O I：

10.1016/j.smim.2009.05.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and non-immune cells. CD40:CD154 interactions mediate T-dependent B cell responses and efficient T cell priming. Thus, CD40 is a likely candidate to play roles in autoimmune diseases in which activated T and B cells cause pathology. Diseases in which CD40 plays a pathogenic role include autoimmune thyroiditis, type 1 diabetes, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. This review discusses the role of CD40:CD154 interaction in human and mouse autoimmunity, human polymorphisms associated with disease incidence, and disrupting CD40: CD154 interactions as an autoimmune therapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：293 / 300

页数：8

共 132 条

[1] Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells [J].