Dynamic covalent polymer hydrogels and organogels crosslinked through acylhydrazone bonds: synthesis, characterization and applications

被引：85

作者：

Apostolides, Demetris E. ^{[1
]}

Patrickios, Costas S. ^{[1
]}

机构：

[1] Univ Cyprus, Dept Chem, 2109 Aglanjia, Nicosia, Cyprus

来源：

POLYMER INTERNATIONAL | 2018年 / 67卷 / 06期

关键词：

dynamic covalent polymers; hydrogels; acylhydrazone; self-healing; drug delivery; tissue engineering; SELF-HEALABLE HYDROGELS; SOL-GEL TRANSITION; HYDRAZONE; OXIME; CATALYSIS; RESPONSIVENESS; CHEMISTRY; NETWORKS; BASE;

D O I：

10.1002/pi.5554

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

We review recent literature on the rapidly expanding field of dynamic covalent polymer networks (DCPNs) crosslinked with acylhydrazone bonds, classified according to their structural perfection: randomly crosslinked and model DCPNs. The dynamic covalent acylhydrazone bond is greatly sensitive to environmental conditions, pH in particular, and is characterized by great stability under neutral and mildly alkaline conditions, and instability under acidic conditions. The dynamic nature of this bond endows DCPNs crosslinked with acylhydrazone bonds with self-healing ability, reversibility and injectability. The last property enables the in vivo site-specific delivery of drugs, biomolecules or cells that have been loaded into DCPN hydrogels. (C) 2018 Society of Chemical Industry

引用

页码：627 / 649

页数：23

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