8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC

被引：296

作者：

Ahmadiyeh, Nasim ^{[1
,3
]}

Pomerantz, Mark M. ^{[1
]}

Grisanzio, Chiara ^{[1
]}

Herman, Paula ^{[1
]}

Jia, Li ^{[4
]}

Almendro, Vanessa ^{[1
]}

He, Housheng Hansen ^{[1
,2
]}

Brown, Myles ^{[1
]}

Liu, X. Shirley ^{[1
,2
]}

Davis, Matt ^{[1
]}

Caswell, Jennifer L. ^{[1
]}

Beckwith, Christine A. ^{[1
]}

Hills, Adam ^{[1
]}

MacConaill, Laura ^{[1
]}

Coetzee, Gerhard A. ^{[5
]}

Regan, Meredith M. ^{[2
]}

Freedman, Matthew L. ^{[1
,6
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Surg, Boston, MA 02115 USA

[4] Washington Univ, Sch Med, Dept Internal Med, Ctr Pharmacogenom, St Louis, MO 63110 USA

[5] Univ So Calif, Norris Canc Ctr, Dept Urol, Los Angeles, CA 90033 USA

[6] Eli & Edythe L Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 21期

基金：

美国国家卫生研究院;

关键词：

chromosome conformation capture; epigenetic; genetics; GENOME-WIDE ASSOCIATION; COLORECTAL-CANCER; ACTIVE CHROMATIN; GENE-EXPRESSION; SUSCEPTIBILITY; VARIANT; ENHANCERS; RS6983267; SCAN;

D O I：

10.1073/pnas.0910668107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism-as tissue-specific enhancers of MYC.

引用

页码：9742 / 9746

页数：5

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