Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection

被引：50

作者：

Alberts, Rudi ^{[1
]}

Srivastava, Barkha ^{[1
]}

Wu, Haiya ^{[1
]}

Viegas, Nuno ^{[1
]}

Geffers, Robert ^{[2
]}

Klawonn, Frank ^{[3
]}

Novoselova, Natalia ^{[4
]}

do Valle, Tania Zaverucha ^{[5
]}

Panthier, Jean-Jacques ^{[5
]}

Schughart, Klaus ^{[1
,6
]}

机构：

[1] Helmholtz Ctr Infect Res, Dept Infect Genet, D-38124 Braunschweig, Germany

[2] Helmholtz Ctr Infect Res, Dept Cell Biol, D-38124 Braunschweig, Germany

[3] Univ Appl Sci Braunschweig Wolfenbuettel, Dept Comp Sci, D-38302 Wolfenbuettel, Germany

[4] Natl Acad Sci Belarus, United Inst Informat Problems, Minsk 220012, BELARUS

[5] Inst Pasteur, Dept Dev Biol, F-75015 Paris, France

[6] Univ Vet Med Hannover, D-30559 Hannover, Germany

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 04期

关键词：

Inbred mouse strains; Influenza A virus; Gene expression microarray; VIRUS-INFECTION; MICROARRAY ANALYSIS; EPITHELIAL-CELLS; IMMUNE-RESPONSE; H5N1; INFECTION; LUNG; MICE; PATHOGENESIS; CHEMOKINES; PNEUMONIA;

D O I：

10.1016/j.micinf.2010.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inbred mouse strains exhibit differences in susceptibility to influenza A infections However. the molecular mechanisms underlying these differences are unknown Therefore, we infected a highly susceptible mouse strain (DBA/2J) and a resistant strain (C5713L/6J) with influenza A H1N1 (PR8) and performed genome-wide expression analysis We found genes expressed in lung epithelium that were specifically down-regulated in DBA/2J mice, whereas a cluster of genes on chromosome 3 was only down-regulated in C57BL/6J In both mouse strains, chemokines, cytokines and interferon-response genes were up-regulated, indicating that the main innate immune defense pathways were activated However. many immune response genes were up-regulated in DBA/2J much stronger than in C57BL/6J, and several immune response genes were exclusively regulated in D13A/2J Thus, susceptible DBA/2J mice showed a hyper-inflammatory response This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus (C) 2010 Elsevier Masson SAS All rights reserved.

引用

页码：309 / 318

页数：10

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