Microbial metabolism of cannflavin A and B isolated from Cannabis sativa

被引：33

作者：

Ibrahim, Amany K. ^{[1
,2
]}

Radwan, Mohamed M. ^{[1
]}

Ahmed, Safwat A. ^{[1
,2
]}

Slade, Desmond ^{[1
]}

Ross, Samir A. ^{[1
,3
]}

ElSohly, Mahmoud A. ^{[1
,4
]}

Khan, Ikhlas A. ^{[1
,3
]}

机构：

[1] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[2] Suez Canal Univ, Dept Pharmacognosy, Fac Pharm, Ismailia 41522, Egypt

[3] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Dept Pharmaceut, University, MS 38677 USA

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 8-9期

关键词：

Microbial metabolism; Cannflavin A; Cannflavin B; Cannabaceae; Cannabis sativa; Mucor ramannianus; Beauveria bassiana; Antifungal activity; Antibacterial activity; Antimalarial activity; Antileishmanial activity; CONSTITUENTS; FLAVONOIDS; VARIETY; CHRYSIN;

D O I：

10.1016/j.phytochem.2010.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L. produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6 '' S,7 ''-dihydroxycannflavin A (3), 6 '' S,7 ''-dihydroxycannflavin A 7-sulfate (4) and 6 '' S,7 ''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'"-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity. (C) 2010 Published by Elsevier Ltd.

引用

页码：1014 / 1019

页数：6

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