Genetic analysis of innate immunity: TIR adapter proteins in innate and adaptive immune responses

被引：19

作者：

Beutler, B ^{[1
]}

Hoebe, K ^{[1
]}

Georgel, P ^{[1
]}

Tabeta, K ^{[1
]}

Du, X ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 15期

关键词：

Toll-like receptors; N-ethyl-N-nitrosourea; innate immunity; forward genetics; mutagenesis; mutation;

D O I：

10.1016/j.micinf.2004.08.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system senses pathogens largely through signals initiated by a collection of phylogenetically related proteins known as "Toll-like receptors" (TLRs), of which 10 representatives are encoded in the human genome. Our understanding of the sensing role played by the TLRs began with the positional cloning of a spontaneous mutation (Lps(d)) in the gene encoding the mammalian lipopolysaccharide (LPS) receptor. Other key innate immunity proteins have been disclosed by germline mutagenesis, and are discussed in the present review. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：1374 / 1381

页数：8

共 51 条

[1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function [J].

Adachi, O ;

Kawai, T ;

Takeda, K ;

Matsumoto, M ;

Tsutsui, H ;

Sakagami, M ;

Nakanishi, K ;

Akira, S .

IMMUNITY, 1998, 9 (01) :143-150

[2] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[3] Vital involvement of a natural killer cell activation receptor in resistance to viral infection [J].

Brown, MG ;

Dokun, AO ;

Heusel, JW ;

Smith, HRC ;

Beckman, DL ;

Blattenberger, EA ;

Dubbelde, CE ;

Stone, LR ;

Scalzo, AA ;

Yokoyama, WM .

SCIENCE, 2001, 292 (5518) :934-937

[4] Combining mutagenesis and genomics in the mouse - Closing the phenotype gap [J].

Brown, SDM ;

Peters, J .

TRENDS IN GENETICS, 1996, 12 (11) :433-435

[5] RELATIONSHIP OF STRUCTURE OF BACTERIAL LIPOPOLYSACCHARIDES TO ITS FUNCTION IN MITOGENESIS AND ADJUVANTICITY [J].

CHILLER, JM ;

SKIDMORE, BJ ;

MORRISON, DC ;

WEIGLE, WO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (07) :2129-2133

[6] RNA interference is mediated by 21-and 22-nucleotide RNAs [J].

Elbashir, SM ;

Lendeckel, W ;

Tuschl, T .

GENES & DEVELOPMENT, 2001, 15 (02) :188-200

[7] Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells [J].

Elbashir, SM ;

Harborth, J ;

Lendeckel, W ;

Yalcin, A ;

Weber, K ;

Tuschl, T .

NATURE, 2001, 411 (6836) :494-498

[8] Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction [J].

Fitzgerald, KA ;

Palsson-McDermott, EM ;

Bowie, AG ;

Jefferies, CA ;

Mansell, AS ;

Brady, G ;

Brint, E ;

Dunne, A ;

Gray, P ;

Harte, MT ;

McMurray, D ;

Smith, DE ;

Sims, JE ;

Bird, TA ;

O'Neill, LAJ .

NATURE, 2001, 413 (6851) :78-83

[9] Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2 [J].

Gantner, BN ;

Simmons, RM ;

Canavera, SJ ;

Akira, S ;

Underhill, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1107-1117

[10] DROSOPHILA TOLL AND IL-1 RECEPTOR [J].

GAY, NJ ;

KEITH, FJ .

NATURE, 1991, 351 (6325) :355-356

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