Detection of house-dust-mite allergen in amniotic fluid and umbilical-cord blood

被引:118
作者
Holloway, JA [1 ]
Warner, JO [1 ]
Vance, GHS [1 ]
Diaper, ND [1 ]
Warner, JA [1 ]
Jones, CA [1 ]
机构
[1] Univ Southampton, Allergy & Inflammat Sci Div, Southampton, Hants, England
关键词
D O I
10.1016/S0140-6736(00)03265-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mononuclear cells In umbilical-cord blood display allergen-specific reactivity, but how allergen exposure occurs In utero is unknown. We Investigated the presence of a common inhalant allergen (Der p 1), to which mothers are exposed throughout pregnancy, by ELISA in matched maternal blood and amniotic fluid samples at 16-17 weeks of gestation, and in matched maternal and umbilical-cord blood at term (greater than or equal to 37 weeks of gestation). Der p 1 was detectable In 24 of 43 amniotic fluid samples where It was also present In maternal blood, and in 15 of 24 cord-plasma samples at significantly higher concentrations than in the maternal plasma (p=0.022). The detection of Der p 1 In the amniotic fluid and the fetal circulation provides direct evidence of transamniotic and transplacental allergen exposure.
引用
收藏
页码:1900 / 1902
页数:3
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