Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist

被引：30

作者：

Palani, A ^{[1
]}

Shapiro, S ^{[1
]}

Clader, JW ^{[1
]}

Greenlee, WJ ^{[1
]}

Blythin, D ^{[1
]}

Cox, K ^{[1
]}

Wagner, NE ^{[1
]}

Strizki, J ^{[1
]}

Baroudy, BM ^{[1
]}

Dan, NY ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01062-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The separation and biological evaluation of rotamers as knell as interconversion studies on rotamers Of Our clinical candidate SCH 351125 are described. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：705 / 708

页数：4

共 20 条

[1] Synthesis of enantioenriched axially chiral anilides from atropisomerically enriched tartarate ortho-anilides [J].

Ates, A ;

Curran, DP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (21) :5130-5131

[2]

BAROUDY B, 2002, AIDS 14 INT C 1

[3] SPONTANEOUS RESOLUTION OF AN AXIALLY DISSYMMETRIC 3-CARBAMOYLPYRIDINIUM IODIDE - INTRINSIC DISCRIMINATION BETWEEN THE ENANTIOMERIC FORMS BY THE INTRODUCTION OF A 2ND CHIRAL ELEMENT [J].

BASTIAANSEN, LAM ;

KANTERS, JA ;

VANDERSTEEN, FH ;

DEGRAAF, AC ;

BUCK, HM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (07) :536-537

[4] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease [J].

Berger, EA ;

Murphy, PM ;

Farber, JM .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :657-700

[5] Atropisomeric amides as chiral ligands: Using (-)-sparteine-directed enantioselective silylation to control the conformation of a stereogenic axis [J].

Clayden, J ;

Johnson, P ;

Pink, JH ;

Helliwell, M .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (21) :7033-7040

[6] IDENTIFICATION OF RANTES, MIP-1-ALPHA, AND MIP-1-BETA AS THE MAJOR HIV-SUPPRESSIVE FACTORS PRODUCED BY CD8(+) T-CELLS [J].

COCCHI, F ;

DEVICO, AL ;

GARZINODEMO, A ;

ARYA, SK ;

GALLO, RC ;

LUSSO, P .

SCIENCE, 1995, 270 (5243) :1811-1815

[7]

HUNT SW, 1998, ANNU REP MED CHEM, V33, P263

[8] Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-carboxamide derivatives as tachykinin NK1 receptor antagonists:: Determination of the absolute stereochemical requirements [J].

Ikeura, Y ;

Ishichi, Y ;

Tanaka, T ;

Fujishima, A ;

Murabayashi, M ;

Kawada, M ;

Ishimaru, T ;

Kamo, I ;

Doi, T ;

Natsugari, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (22) :4232-4239

[9] Chemokine receptors: Keys to AIDS pathogenesis? [J].

Littman, DR .

CELL, 1998, 93 (05) :677-680

[10] Frequency of CCR5 genotypes in HIV-infected patients in Roraima, Brazil [J].

Guerra Corado, Andre de Lima ;

Villarouco da Silva, George Allan ;

Carvalho Leao, Renato Augusto ;

Granja, Fabiana ;

Naveca, Felipe Gomes .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2016, 20 (03) :314-315

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