Inhibition of angiogenesis with humanized monoclonal antibodies to vascular endothelial growth factor (VEGF) or with tyrosine kinase inhibitors targeting VEGF receptors has become an established treatment for various tumor types. Contrary to expectations, angiogenesis inhibition by blocking VEGF-mediated signaling is associated with serious side effects including hypertension and renal and cardiac toxicity in a substantial proportion of patients. Fortunately, most of these side effects as discussed in this paper seem to be manageable, but likely become more problematic when survival increases. Although several hypotheses regarding the etiology of angiogenesis inhibition-related cardiovascular and renal side effects have been postulated, many of the underlying pathophysiological mechanisms remain to be elucidated. This may lead to the development of more specific angiogenesis inhibitors, better management of their side effects and may potentially provide new insights into the pathogenesis of cardiovascular disease in general. J Hypertens 27:2297-2309 (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Banfor, Patricia N.
;
Franklin, Pamela A.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Franklin, Pamela A.
;
Segreti, Jason A.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Segreti, Jason A.
;
Widomski, Deborah L.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Widomski, Deborah L.
;
Davidsen, Steven K.
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Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Davidsen, Steven K.
;
Albert, Daniel H.
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Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Albert, Daniel H.
;
Cox, Bryan F.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Cox, Bryan F.
;
Fryer, Ryan M.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Fryer, Ryan M.
;
Gintant, Gary A.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
机构:
Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England
Board, Ruth E.
;
Thistlethwaite, Fiona C.
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Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England
Thistlethwaite, Fiona C.
;
Hawkins, Robert E.
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Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Banfor, Patricia N.
;
Franklin, Pamela A.
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机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Franklin, Pamela A.
;
Segreti, Jason A.
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Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Segreti, Jason A.
;
Widomski, Deborah L.
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h-index: 0
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Widomski, Deborah L.
;
Davidsen, Steven K.
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h-index: 0
机构:
Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Davidsen, Steven K.
;
Albert, Daniel H.
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h-index: 0
机构:
Abbott Labs, Canc Res, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Albert, Daniel H.
;
Cox, Bryan F.
论文数: 0引用数: 0
h-index: 0
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Cox, Bryan F.
;
Fryer, Ryan M.
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h-index: 0
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
Fryer, Ryan M.
;
Gintant, Gary A.
论文数: 0引用数: 0
h-index: 0
机构:
Abbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USAAbbott Labs, Dept Integrat Pharmacol, Global Pharmaceut Res & Dev, Abbott Pk, IL 60064 USA
机构:
Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England
Board, Ruth E.
;
Thistlethwaite, Fiona C.
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机构:
Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England
Thistlethwaite, Fiona C.
;
Hawkins, Robert E.
论文数: 0引用数: 0
h-index: 0
机构:
Christie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, EnglandChristie Hosp NHS Trust, Dept Med Oncol, Canc Res UK, Manchester M20 4BX, Lancs, England