Safety of a patented special butterbur root extract for migraine prevention

被引：25

作者：

Danesch, U ^{[1
]}

Rittinghausen, R ^{[1
]}

机构：

[1] Weber & Weber GmbH & CoKG, D-82266 Inning, Germany

来源：

HEADACHE | 2003年 / 43卷 / 01期

关键词：

Petasites hybridus; butterbur; migraine; safety; toxicity; mutagenicity; adverse effects;

D O I：

10.1046/j.1526-4610.2003.03015.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective.-To report on the safety of a patented special butterbur root extract used for migraine prevention. Background.-Two placebo-controlled clinical trials have been conducted supporting the beneficial use in humans. Methods.-Results from acute, subchronic and chronic animal toxicity studies as well as from mutagenicity studies are reported. Safety data gained from clinical trials, postmarketing surveillance studies and pharmacovigilance are evaluated and discussed. Conclusion.-The patented special butterbur root extract is safe for the treatment in humans.

引用

页码：76 / 78

页数：3

共 19 条

[1]

AEBI A, 1955, PHARM ACTA HELV, V29, P277

[2]

BARSOM S, 1986, ERFAHRUNGSHEILKUNDE, V35, P1

[3]

Bauer H, 1986, THERAPIEWOCHE, V36, P3756

[4]

BOMMER S, 1995, SCHWEIZ Z GANZHEITSM, V5, P254

[5]

Bucher K., 1950, ARCH EXP PATHOL PH, V213, P69

[6]

GOBEL H, 2001, SCHMERZ S1, V15

[7]

Grossmann M, 2000, INT J CLIN PHARM TH, V38, P430

[8]

Gruia F.S., 1987, BIOL MED PARIS, V3, P454

[9]

GRUIA FS, 1986, ERFAHRUNGSHEILKUNDE, V35, P396

[10] Causes, epidemiology, and clinical evaluation of suspected herbal poisoning [J].

Ko, RJ .

JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 1999, 37 (06) :697-708

← 1 2 →