Further antineoplastic terpenylquinones and terpenylhydroquinones

被引：32

作者：

del Corral, JM

Gordaliza, M ^{[1
]}

Castro, A

Mahiques, MM

San Feliciano, A

Garcia-Gravalos, MD

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain

[2] PharmaMar SA, E-28760 Madrid, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 01期

关键词：

avarol; terpenyl-naphthoquinones/naphthohydroquinones antineoplastic; cytotoxicity;

D O I：

10.1016/S0968-0896(97)10007-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influences of the quinone/hydroquinone fragment and other structural features are considered in relation with the antineoplastic activity and selectivity of terpenylquinones/hydroquinones. Several compounds have shown IC50 values under the mu M level. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：31 / 41

页数：11

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