Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant

被引：147

作者：

Vogelsang, GB ^{[1
]}

Lee, L ^{[1
]}

Bensen-Kennedy, DM ^{[1
]}

机构：

[1] Johns Hopkins, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

ANNUAL REVIEW OF MEDICINE-SELECTED TOPICS IN THE CLINICAL SCIENCES | 2003年 / 54卷

关键词：

stem cell transplantation; prednisone; donor lymphocyte infusion; sclerodermatous;

D O I：

10.1146/annurev.med.54.101601.152339

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.

引用

页码：29 / 52

页数：26

共 85 条

[1] Development of a prognostic model for grading chronic graft-versus-host disease [J].

Akpek, G ;

Zahurak, ML ;

Piantadosi, S ;

Margolis, J ;

Doherty, J ;

Davidson, R ;

Vogelsang, GB .

BLOOD, 2001, 97 (05) :1219-1226

[2] Immunomodulatory effects of extracorporeal photochemotherapy in patients with extensive chronic graft-versus-host disease [J].

Alcindor, T ;

Gorgun, G ;

Miller, KB ;

Roberts, TF ;

Sprague, K ;

Schenkein, DP ;

Foss, FM .

BLOOD, 2001, 98 (05) :1622-1625

[3] A phase I/II double-blind, placebo-controlled study of recombinant human interleukin-11 for mucositis and acute GVHD prevention in allogeneic stem cell transplantation [J].

Antin, JH ;

Lee, SJ ;

Neuberg, D ;

Alyea, E ;

Soiffer, RJ ;

Sonis, S ;

Ferrara, JLM .

BONE MARROW TRANSPLANTATION, 2002, 29 (05) :373-377

[4] A systematic approach to hepatic complications in hematopoietic stem cell transplantation [J].

Arai, S ;

Lee, LA ;

Vogelsang, GB .

JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2002, 11 (02) :215-229

[5] Management of graft-versus-host disease [J].

Arai, S ;

Vogelsang, GB .

BLOOD REVIEWS, 2000, 14 (04) :190-204

[6] Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO) [J].

Bacigalupo, A ;

Lamparelli, T ;

Bruzzi, P ;

Guidi, S ;

Alessandrino, PE ;

di Bartolomeo, P ;

Oneto, R ;

Bruno, B ;

Barbanti, M ;

Sacchi, N ;

Van Lint, MT ;

Bosi, A .

BLOOD, 2001, 98 (10) :2942-2947

[7] The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice [J].

Baker, MB ;

Altman, NH ;

Podack, ER ;

Levy, RB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) :2645-2656

[8] TREATMENT OF MURINE LEUKAEMIA WITH X-RAYS AND HOMOLOGOUS BONE MARROW - PRELIMINARY COMMUNICATION [J].

BARNES, DWH ;

CORP, MJ ;

LOUTIT, JF ;

NEAL, FE .

BRITISH MEDICAL JOURNAL, 1956, 2 (SEP15) :626-627

[9] New immunosuppressants in BMT/GVHD [J].

Basara, N ;

Günzelmann, S ;

Willenbacher, W ;

Fauser, AA ;

Kiehl, MG .

TRANSPLANTATION PROCEEDINGS, 2001, 33 (03) :2220-2222

[10]

Billingham R E, 1966, Harvey Lect, V62, P21

← 1 2 3 4 5 6 7 8 9 →