The role of SMC proteins in the responses to DNA damage

被引：84

作者：

Lehmann, AR ^{[1
]}

机构：

[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

DNA REPAIR | 2005年 / 4卷 / 03期

关键词：

cohesin; condensin; homologous recombination; Smc5-6; complex;

D O I：

10.1016/j.dnarep.2004.07.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：309 / 314

页数：6

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