Fatigue and basal ganglia

被引：487

作者：

Chaudhuri, A ^{[1
]}

Behan, PO ^{[1
]}

机构：

[1] Univ Glasgow, So Gen Hosp, Dept Neurol, Inst Neurol Sci, Glasgow G51 4TF, Lanark, Scotland

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2000年 / 179卷 / 1-2期

关键词：

fatigue; basal ganglia; limbic system; dopamine; serotanin; thalamo-cortical loop; chronic fatigue syndrome;

D O I：

10.1016/S0022-510X(00)00411-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fatigue is a common symptom in neurology and occurs in the diseases of the central and peripheral nervous system. In order to understand the mechanism of fatigue, it is important to distinguish symptoms of peripheral neuromuscular fatigue from the symptoms of physical and mental fatigue characteristic of disorders like Parkinson's disease or multiple sclerosis. We have introduced and defined the concept of central fatigue for the latter disorders. We have further proposed, with supportive neuropathological data, that central fatigue may occur due to a failure in the integration of the limbic input and the motor functions within the basal ganglia affecting the striatal-thalamic-frontal cortical system. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：34 / 42

页数：9

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