Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

被引：37

作者：

Bader, S ^{[1
]}

Walker, M ^{[1
]}

Harrison, D ^{[1
]}

机构：

[1] Univ Edinburgh, Mol Med Ctr, Dept Pathol, Sir Alastair Currie CRC Labs, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2000年 / 83卷 / 12期

关键词：

MBD4; colorectal cancer; microsatellite instability;

D O I：

10.1054/bjoc.2000.1482

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The MSD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides, In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported. (C) 2000 Cancer Research Campaign.

引用

页码：1646 / 1649

页数：4

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