2-substituted 3-aryl- and 3-heteroarylindoles by the palladium-catalyzed reaction of o-trifluoroacetanilides with aryl bromides and triflates

被引：59

作者：

Cacchi, S

Fabrizi, G

Lamba, D

Marinelli, F

Parisi, LM

机构：

[1] Univ Roma La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biol At, I-00185 Rome, Italy

[2] CNR Trieste, Inst Struct Chem, XRDI Beamline, Elettra Trieste, Italy

[3] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, Fac Sci, I-67100 Laquila, Italy

来源：

SYNTHESIS-STUTTGART | 2003年 / 05期

关键词：

palladium; alkynes; indoles; aryl halides; cyclization;

D O I：

10.1055/s-2003-38079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed reaction of aryl and heteroaryl bromides and triflates with o-alkynyltrifluoroacetanilides affords 2-substituted 3-aryl- and heteroarylindoles usually in excellent yield. The procedure can be applied to the synthesis of 2-substituted indole-3-carboxaldehydes.

引用

页码：728 / 734

页数：7

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