Enzyme-responsive polymer hydrogel particles for controlled release

被引：233

作者：

Thornton, Paul D.

Mart, Robert J.

Ulijn, Rein V.

机构：

[1] Sch Mat, Manchester M1 7HS, Lancs, England

[2] MIB, Manchester M1 7HS, Lancs, England

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1002/adma.200601784

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).

引用

页码：1252 / +

页数：6

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