Multidrug resistance in glioblastoma. Chemosensitivity resting and immunohistochemical demonstration of p-glycoprotein

被引:28
作者
Leweke, F
Damian, MS
Schindler, C
Schachenmayr, W
机构
[1] Univ Giessen, Neurol Clin, D-35385 Giessen, Germany
[2] Univ Giessen, Dept Neuropathol, D-35385 Giessen, Germany
关键词
chemosensitivity test; glioblastoma; MTT assay; multidrug resistance; p-glycoprotein;
D O I
10.1016/S0344-0338(98)80015-0
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Chemosensitivity of previously untreated glioblastomas to mitoxantrone, methotrexate, ACNU and BCNU was tested on cultured tissue. Sixteen of 62 tumors were partially chemosensitive in vitro. The monoclonal antibody C 219 was used to demonstrate the presence of p-glycoprotein in the 16 sensitive and five highly resistant glioblastomas. All 21 tumors identically expressed p-glycoprotein. These results show that untreated glioblastomas primarily express p-glycoprotein even if they are at least partially chemosensitive in vitro. There fore, immunohistochemical demonstration of p-glycoprotein with the monoclonal antibody C 219 can not provide reliable information on short term resistance of the individual tumors to antineoplastic drugs. P-glycoprotein expression could, however, help to explain the disappointing overall long-term efficacy of chemotherapy by showing the existence of cell populations with early drug resistance in these tumors.
引用
收藏
页码:149 / 155
页数:7
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