Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK

被引：281

作者：

Ix, Joachim H. ^{[2
,3
]}

Sharma, Kumar ^{[1
]}

机构：

[1] Univ Calif San Diego, Ctr Renal Translat Med, Vet Affairs San Diego Healthcare Syst, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Dept Med, Vet Affairs San Diego Healthcare Syst, Div Nephrol & Hypertens, San Diego, CA 92103 USA

[3] Univ Calif San Diego, Dept Family & Prevent Med, Div Prevent Med, San Diego, CA 92103 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2010年 / 21卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; MOLECULAR-WEIGHT-ADIPONECTIN; MESSENGER-RNA TRANSLATION; CORONARY-HEART-DISEASE; STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY; INSULIN-RESISTANCE; PLASMA ADIPONECTIN; METABOLIC SYNDROME; SERUM ADIPONECTIN;

D O I：

10.1681/ASN.2009080820

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.

引用

页码：406 / 412

页数：7

共 92 条

[1] High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase [J].

Adachi, Masayuki ;

Brenner, David A. .

HEPATOLOGY, 2008, 47 (02) :677-685

[2] Resveratrol alleviates alcoholic fatty liver in mice [J].

Ajmo, Joanne M. ;

Liang, Xiaomei ;

Rogers, Christopher Q. ;

Pennock, Brandi ;

You, Min .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 295 (04) :G833-G842

[3] Review article: role of oxidative stress in the progression of non-alcoholic steatosis [J].

Albano, E ;

Mottaran, E ;

Occhino, G ;

Reale, E ;

Vidali, M .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2005, 22 :71-73

[4] Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease [J].

Angulo, P ;

Alba, LM ;

Petrovic, LM ;

Adams, LA ;

Lindor, KD ;

Jensen, MD .

JOURNAL OF HEPATOLOGY, 2004, 41 (06) :943-949

[5] Site and mechanism of leptin action in a rodent form of congenital lipodystrophy [J].

Asilmaz, E ;

Cohen, P ;

Miyazaki, M ;

Dobrzyn, P ;

Ueki, K ;

Fayzikhodjaeva, G ;

Soukas, AA ;

Kahn, CR ;

Ntambi, JM ;

Socci, ND ;

Friedman, JM .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (03) :414-424

[6] CHARACTERIZATION OF A NATURAL INHIBITOR OF THE INSULIN-RECEPTOR TYROSINE KINASE - CDNA CLONING, PURIFICATION, AND ANTI-MITOGENIC ACTIVITY [J].

AUBERGER, P ;

FALQUERHO, L ;

CONTRERES, JO ;

PAGES, G ;

LECAM, G ;

ROSSI, B ;

LECAM, A .

CELL, 1989, 58 (04) :631-640

[7] Is fetuin-A/α2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease? [J].

Axelsson, Jonas ;

Wang, Xin ;

Ketteler, Markus ;

Qureshi, Abdul Rashid ;

Heimburger, Olof ;

Barany, Peter ;

Lindholm, Bengt ;

Nordfors, Louise ;

Stenvinkel, Peter .

AMERICAN JOURNAL OF NEPHROLOGY, 2008, 28 (04) :669-676

[8] A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis [J].

Belfort, Renata ;

Harrison, Stephen A. ;

Brown, Kenneth ;

Darland, Celia ;

Finch, Joan ;

Hardies, Jean ;

Balas, Bogdan ;

Gastaldelli, Amalia ;

Tio, Fermin ;

Pulcini, Joseph ;

Berria, Rachele ;

Ma, Jennie Z. ;

Dwivedi, Sunil ;

Havranek, Russell ;

Fincke, Chris ;

DeFronzo, Ralph ;

Bannayan, George A. ;

Schenker, Steven ;

Cusi, Kenneth .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (22) :2297-2307

[9] Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity [J].

Bugianesi, E ;

Pagotto, U ;

Manini, R ;

Vanni, E ;

Gastaldelli, A ;

de Iasio, R ;

Gentilcore, E ;

Natale, S ;

Cassader, M ;

Rizzetto, M ;

Pasquali, R ;

Marchesini, G .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3498-3504

[10] A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats [J].

Carmiel-Haggai, M ;

Cederbaum, AI ;

Nieto, N .

FASEB JOURNAL, 2004, 18 (14) :136-+

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