Kinetic isotope effects for the C-H activation step in phase-transfer halogenations of alkanes

被引：16

作者：

Lauenstein, O

Fokin, AA

Schreiner, PR

机构：

[1] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

[2] Kiev Polytech Inst, Dept Organ Chem, UA-252056 Kiev, Ukraine

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol0059347

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Within the scope of phase-transfer halogenations (Br and I) of alkanes, significant HID kinetic isotope effects (KIE = 4-5) indicate that hydrogen abstraction is rate limiting. The excellent agreement of computed and experimentally determined H/D KIE as well as trapping experiments support the involvement of trihalomethyl radicals in the activation step.

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页码：2201 / 2204

页数：4

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