Cortical Spreading Depression and Migraine

被引：87

作者：

Eikermann-Haerter, Katharina ^{[4
,5
]}

Ayata, Cenk ^{[1
,2
,3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Stroke Serv, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Neurol, Neurosci Intens Care Unit, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Radiol, Neurovasc Res Lab, Charlestown, MA 02129 USA

[5] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

来源：

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS | 2010年 / 10卷 / 03期

关键词：

Cortical spreading depression (CSD); Migraine; Familial hemiplegic migraine (FHM); Hormones; Aura; Trigger; FAMILIAL HEMIPLEGIC MIGRAINE; TRIGEMINAL NUCLEUS; NEOCORTICAL SLICES; CALCIUM-CHANNELS; CLASSIC MIGRAINE; CEREBRAL-CORTEX; MOUSE MODELS; MUTANT MICE; CA2+ INFLUX; HUMAN BRAIN;

D O I：

10.1007/s11910-010-0099-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cortical spreading depression, a slowly propagating wave of transient neuronal and glial depolarization, is widely accepted as the electrophysiologic substrate of migraine aura and a trigger for headache. Recent clinical and experimental evidence reinforces the putative role of cortical spreading depression in migraine pathophysiology. Imaging studies in migraineurs demonstrated hemodynamic changes consistent with cortical spreading depression during aura, whereas recent animal studies helped unravel pathophysiologic aspects such as the triggering mechanisms, genetic and hormonal modulation, and potential therapeutic targets. Here, we provide an overview of recent advances in our understanding of migraine pathophysiology and treatment.

引用

页码：167 / 173

页数：7

共 76 条

[1] Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness [J].