Oxidants, oxidative stress and the biology of ageing

被引：7456

作者：

Finkel, T

Holbrook, NJ

机构：

[1] NHLBI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

[2] NIA, Biol Chem Lab, NIH, Baltimore, MD 21224 USA

来源：

NATURE | 2000年 / 408卷 / 6809期

关键词：

D O I：

10.1038/35041687

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

引用

页码：239 / 247

页数：9

共 109 条

[1] Reactive oxygen species as mediators of signal transduction in cardiovascular disease [J].