Concurrence of inflammatory bowel disease and multiple sclerosis

被引:88
作者
Kimura, K
Hunter, SF
Thollander, MS
Loftus, EV
Melton, LJ
O'Brien, PC
Rodriguez, M
Phillips, SF
机构
[1] Mayo Clin & Mayo Fdn, Gastroenterol Res Unit, Dept Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Duv Gastroenterol & Hepatol & Internal Med, Rochester, MN 55905 USA
[4] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA
关键词
D O I
10.4065/75.8.802
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To quantify the coexistence of inflammatory bowel disease (IBD) and multiple sclerosis (MS) and to characterize the diseases when they coexist, Patients and Methods: In this retrospective study of medical records spanning 1950 through 1995, the diagnoses of Crohn disease (CD), ulcerative colitis (UC), and MS were based on review of inpatient and outpatient records by a gastroenterologist and a neurologist, Results: We identified 4 residents of Olmsted County, Minnesota, with IBD (3 UC, I CD) who had concurrent, clinically definite MS; all had mild neurologic disease with little disability. These comprised 1% of the IBD and 1.8% of the MS cohort, The CD patient had undergone terminal ileal resection; of the UC patients, 2 had pancolitis, and I had proctosigmoiditis. The observed prevalence of MS at onset of IBD was 3.7 times the expected (95% confidence interval, 0.8-10.8), We also reviewed the records of 32 referral patients with both diagnoses. Disability from MS was moderate at median follow-up of 8.5 Sears. By 15 years, ambulation was impaired in most patients. Neurologic disability was similar between patients with CD and UC, Conclusions: Concurrence of the 2 diseases was greater than expected. Although MS and IBD may share common predisposing factors, not enough information is available to speculate about possible mechanisms.
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页码:802 / 806
页数:5
相关论文
共 30 条
[1]   ARE FOCAL WHITE-MATTER LESIONS IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE LINKED TO MULTIPLE-SCLEROSIS [J].
AGRANOFF, D ;
SCHON, F .
LANCET, 1995, 346 (8968) :190-191
[2]  
BINDER V, 1982, GASTROENTEROLOGY, V83, P563
[3]   CROHNS-DISEASE AND MULTIPLE-SCLEROSIS - A SINGLE-CASE REPORT [J].
BUCCINO, GP ;
CORRENTE, G ;
VISINTINI, D .
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1994, 15 (06) :303-306
[4]   Symptomatic cerebral microangiopathy preceding initial manifestation of ulcerative colitis [J].
Dejaco, C ;
Fertl, E ;
Prayer, D ;
Oberhuber, G ;
Wyatt, J ;
Gasche, C ;
Gangl, A .
DIGESTIVE DISEASES AND SCIENCES, 1996, 41 (09) :1807-1810
[5]  
GEISSLER A, 1995, LANCET, V345, P897
[6]   EPIDEMIOLOGIC ASPECTS OF CROHNS-DISEASE - A POPULATION BASED STUDY IN OLMSTED COUNTY, MINNESOTA, 1943-1982 [J].
GOLLOP, JH ;
PHILLIPS, SF ;
MELTON, LJ ;
ZINSMEISTER, AR .
GUT, 1988, 29 (01) :49-56
[7]   EXPERIMENTAL THERAPIES FOR MULTIPLE-SCLEROSIS - CURRENT STATUS [J].
GOODKIN, DE ;
RANSOHOFF, RM ;
RUDICK, RA .
CLEVELAND CLINIC JOURNAL OF MEDICINE, 1992, 59 (01) :63-74
[8]   THE EPIDEMIOLOGY OF MULTIPLE-SCLEROSIS IN QUEENSLAND, AUSTRALIA [J].
HAMMOND, SR ;
DEWYTT, C ;
MAXWELL, IC ;
LANDY, PJ ;
ENGLISH, D ;
MCLEOD, JG ;
MCCALL, MG .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 1987, 80 (2-3) :185-204
[9]   CROHNS-DISEASE IN A PATIENT WITH MULTIPLE-SCLEROSIS [J].
KITCHIN, LI ;
KNOBLER, RL ;
FRIEDMAN, LS .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1991, 13 (03) :331-334
[10]   EPIDEMIOLOGIC CONTRIBUTIONS TO MULTIPLE-SCLEROSIS - AN OVERVIEW [J].
KURTZKE, JF .
NEUROLOGY, 1980, 30 (07) :61-79