Quantitative structure-activity relationships of phenolic compounds causing apoptosis

被引：24

作者：

Hansch, C

Bonavida, B

Jazirehi, AR

Cohen, JJ

Milliron, C

Kurup, A

机构：

[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA

[2] Univ Colorado, Sch Med, Dept Immunol, Denver, CO 80262 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0968-0896(02)00326-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A study of a variety of phenolic compounds (simple phenols, estradiol, bisphenol A, diethylstilbesterol) on their action on L1210 leukemia cells led to the formulation of the following QSAR for apoptosis: log 1/C= -3.16 Clog P+2.77 CMR-3.76 n=11, r(2)=0.939, s=0.630, q(2)=0.892 C is the molar concentration causing 25% apoptosis, Clog P is the calculated octanol/water partition coefficient and CMR is the calculated molecular refractivity. Our results imply the significance of characterization of the phenolic compounds with apoptotic activity and the development of new agents for cancer therapy. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：617 / 620

页数：4

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