CSF characteristics in early-onset multiple sclerosis

被引：123

作者：

Pohl, D

Rostasy, K

Reiber, H

Hanefeld, F

机构：

[1] Univ Gottingen, Dept Pediat & Pediat Neurol, D-37075 Gottingen, Germany

[2] Univ Gottingen, Dept Neurol, Neurochem Lab, D-37075 Gottingen, Germany

来源：

NEUROLOGY | 2004年 / 63卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000144352.67102.BC

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors studied CSF characteristics in 136 patients with multiple sclerosis ( MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.

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页码：1966 / 1967

页数：2

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