Low Levels of Hydrogen Sulfide in the Blood of Diabetes Patients and Streptozotocin-Treated Rats Causes Vascular Inflammation?

被引：256

作者：

Jain, Sushil K. ^{[1
]}

Bull, Rebeca ^{[1
]}

Rains, Justin L. ^{[1
]}

Bass, Pat F. ^{[1
,2
]}

Levine, Steven N. ^{[2
]}

Reddy, Sudha ^{[1
]}

McVie, Robert ^{[1
]}

Bocchini, Joseph A., Jr. ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Pediat, Hlth Sci Ctr, Shreveport, LA 71130 USA

[2] Louisiana State Univ, Dept Med, Hlth Sci Ctr, Shreveport, LA 71130 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2010年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

OXIDATIVE STRESS; GLUCOSE; HYPERTENSION; ADOLESCENTS; RESISTANCE; ISCHEMIA;

D O I：

10.1089/ars.2009.2956

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide (H2S) is emerging as a physiological neuromodulator as well as a smooth muscle relaxant. We submit the first evidence that blood H2S levels are significantly lower in fasting blood obtained from type 2 diabetes patients compared with age-matched healthy subjects, and in streptozotocin-treated diabetic rats compared with control Sprague-Dawley rats. We further observed that supplementation with H2S or an endogenous precursor of H2S (L-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes. These first observations led to the hypothesis that lower blood H2S levels may contribute to the vascular inflammation seen in diabetes. Antioxid. Redox Signal. 12, 1333-1338.

引用

页码：1333 / 1337

页数：5

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