Immune evasion by cytomegalovirus - survival strategies of a highly adapted opportunist

被引：180

作者：

Hengel, H ^{[1
]}

Brune, W ^{[1
]}

Koszinowski, UH ^{[1
]}

机构：

[1] Univ Munich, Max Von Pettenkofer Inst, Dept Virol, Gene Ctr, D-81377 Munich, Germany

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0966-842X(98)01255-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Slowly replicating, species-specific and complex DNA viruses, such as cytomegaloviruses (CMVs), which code for >200 antigenic proteins, should be easy prey to the host's immune system. Yet, CMVs are amazingly adapted opportunists that cope with multiple immune responses. Frequently, CMVs exploit immune mechanisms generated by the host. These strategies secure the persistence of CMVs and provide opportunities to spread to naive individuals.

引用

页码：190 / 197

页数：8

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